Pennathur Lab

Division of Nephrology - Department of Internal Medicine

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  • The Group
    The Group
  • Agilent 6410 Triple Quadrupole (QQQ) Mass Spectrometer with HPLC
    Agilent 6410 Triple Quadrupole (QQQ) Mass Spectrometer with HPLC
  • Autosampler
    Autosampler
  • Diabetic and Control
    Diabetic and Control
  • Heatmap
    Heatmap
  • Agilent  Mass Spec Screen Shot
    Agilent Mass Spec Screen Shot
  • Peak Data
    Peak Data
  • Aorta’s, control vs high fat diet
    Aorta’s, control vs high fat diet

The central theme of our research has focused on the applications of biological mass spectrometry in disease pathogenesis. A major focus of the lab has been to define the role of oxidative stress on disease pathogenesis and complications, including diabetic complications, chronic kidney disease, autoimmune disease and cardiovascular disease. We have utilized mass spectrometry to identify key protein and metabolite alterations in disease states and tested the hypothesis whether these alterations predict complications in animal models and humans. Our strategy has been to develop analytical techniques in animal models and validate these markers in humans and then interrogating the animal model for biological pathway relevance. Recent extensions of this work have included targeted as well as untargetted metabolomic and proteomic profiling.