Pennathur Lab

Division of Nephrology - Department of Internal Medicine

Lab Members


Subramaniam Pennathur, M.D.
Department of Internal Medicine-Nephrology
Nephrology Division Chief
spennath@umich.edu
PubMed Listing

The central theme of our research has focused on the applications of biological mass spectrometry in disease pathogenesis. A major focus of the lab has been to define the role of oxidative stress on disease pathogenesis and complications, including diabetic complications, chronic kidney disease, autoimmune disease and cardiovascular disease. We have utilized mass spectrometry to identify key protein and metabolite alterations in disease states and tested the hypothesis whether these alterations predict complications in animal models and humans. Our strategy has been to develop analytical techniques in animal models and validate these markers in humans and then interrogating the animal model for biological pathway relevance. Recent extensions of this work have included targeted as well as untargetted metabolomic and proteomic profiling.

Dr. Pennathur completed his clinical training in Internal Medicine, Endocrinology and Nephrology at Washington University, Saint Louis, where he served as Chief Resident. He then completed research fellowships at Massachusetts General Hospital in Boston, Washington University in Saint Louis, and the University of Washington, Seattle.

Dr. Pennathur serves as the Director of the Molecular Phenotyping and Metabolomics Core, and the Physician Scientist Program in the Department of Medicine. His laboratory’s research is funded by the National Institutes of Health, and foundations including the Juvenile Diabetes Research Foundation.

Team Members

Team Member Job Title E-mail
Farsad Afshinnia M.D., M.S.

Assistant Professor, Department of Internal Medicine-Nephrology

fafshin@med.umich.edu
Judy Baek

MD/PhD candidate

judybaek@umich.edu
Jaeman Byun, Ph.D.

Associate Research Scientist

jaemanb@umich.edu
Adil Jadoon, M.D.

Nephrology Fellow, Department of Internal Medicine-Nephrology

ajadoon@med.umich.edu
Pradeep Kayampilly, Ph.D.

Research Laboratory Specialist, Department of Internal Medicine-Nephrology

prapeepk@med.umich.edu
Anna Mathew, M.D.

Assistant Professor, Department of Internal Medicine-Nephrology

amat@med.umich.edu
Kelli Sas, Ph.D.

Research Investigator, Department of Internal Medicine-Nephrology

sask@med.umich.edu
Thommey Thomas, Ph.D.

Research Associate, Department of Internal Medicine-Nephrology

thommey@med.umich.edu
Stefanie Wernisch, Ph.D.

Research Fellow, Department of Internal Medicine-Nephrology

wernisch@med.umich.edu
Lixia Zeng, Ph.D.

Research Laboratory Specialist, Department of Internal Medicine-Nephrology

lixiaze@med.umich.edu
Nancy Roeser

Lab Manager, Research Laboratory Specialist, Department of Internal Medicine-Nephrology

nroeser@med.umichi.edu